Cell umbrella protects stem cells from DNA damage

Tissue-specific stem cells have the crucial role of maintaining and replenishing all the specialized cells that make up a given tissue or system, so it is essential that their functions are preserved throughout an organism’s life. These adult stem cells therefore reside in dedicated microenvironments called stem cell niches, which help to regulate and protect the stem cells. In a paper in Nature, Friedrich Kapp, M.D., who at the time of the study was at the Harvard Stem Cell Institute, and colleagues investigated factors that affect the locations of niches for hematopoietic stem and progenitor cells (HSPCs), which give rise to all blood-cell lineages.

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